Biphenyl hydroxamate inhibitors of matrix metalloproteinases
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United States of America Patent
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Sep 9, 1997
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N/A
app pub date -
Nov 14, 1995
filing date -
Nov 14, 1995
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Expired
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Abstract
Compounds of formula ##STR1## or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF.alpha. secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF.alpha. secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF.alpha. secretion.
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