Assays for nucleosome remodeling activity

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United States of America Patent

PATENT NO 11493520
APP PUB NO 20200200766A1
SERIAL NO

16614692

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Abstract

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The invention relates to assays for nucleosome remodeling activity using functionalized recombinant mononucleosomes. The functionalized recombinant mononucleosomes comprise a histone octamer comprising recombinant histone H2A, H2B, H3 and H4 proteins and a DNA template comprising a nucleosome positioning sequence that effectively positions the histone octamer and a signal site. The invention further relates to methods of using the assay to quantify enzymatic activity of remodeling enzymes and identifying modulators of remodeling enzyme activity.

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Patent Owner(s)

  • EPICYPHER, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cowles, Martis William Chapel Hill, US 6 0
Keogh, Michael-Christopher Cambridge, US 8 0
Whelihan, Matthew Fruge Durham, US 1 0

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