Delivery of compacted nucleic acid to cells
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United States of America Patent
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Jun 20, 2000
Issued Date -
N/A
app pub date -
Jul 13, 1998
filing date -
Mar 23, 1994
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Nucleic acids are compacted, substantially without aggregation, to facilitate their uptake by target cells of an organism to which the compacted material is administered. The nucleic acids may achieve a clinical effect as a result of gene expression, hybridization to endogenous nucleic acids whose expression is undesired, or site-specific integration so that a target gene is replaced, modified or deleted. The targeting may be enhanced by means of a target cell-binding moiety. The nucleic acid is preferably compacted to a condensed state.
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