Bryostatin compounds and methods of preparing the same

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United States of America Patent

PATENT NO 11746105
SERIAL NO

17162554

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Abstract

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Methods for preparing a variety of bryostatin compounds are provided. The subject methods provide for preparation of bryostatin 1 in multi-gram quantities in a low and unprecedented number of convergent synthetic steps from commercially available materials. The subject methods are scalable with low estimated material costs and can provide enough material to meet clinical needs. Also provided are a variety of bryostatin analog compounds, and prodrug forms thereof, which are synthetically accessible via the subject methods and pharmaceutical compositions including the same.

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Patent Owner(s)

  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hardman, Clayton Stanford, US 6 2
Ho, Stephen Stanford, US 37 337
Jeffreys, Matthew S King of Prussia, US 3 1
Quiroz, Ryan Boston, US 6 1
Ryckbosch, Steven Albany, US 3 1
Shimizu, Akira Stanford, US 333 15369
Sloane, Jack Stanford, US 4 3
Stevens, Matthew C Atherton, US 3 1
Wender, Paul Stanford, US 12 15

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