Stable cell line secreting Chikungunya Virus (CHIKV) virus like particles (VLP) for vaccines

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United States of America Patent

PATENT NO 11827675
APP PUB NO 20210163544A1
SERIAL NO

17268573

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Abstract

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The present invention includes nucleic acids, proteins, Chikungunya virus (CHIKV) Virus Like Particles (VLP), and methods of making a Chikungunya virus (CHIKV) Virus Like Particles (VLP) comprising: inserting one or more nucleic acids into a lentiviral backbone, wherein the nucleic acid encodes one or more Chikungunya virus (CHIKV) proteins; transfecting the one or more nucleic acids into the lentiviral backbone into a cell line; culturing the transfected cell line under conditions in which the Chikungunya virus (CHIKV) Virus Like Particles (VLP) are released from the cell line; and isolating the Chikungunya virus (CHIKV) Virus Like Particles (VLP) from a culture supernatant.

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Patent Owner(s)

Patent OwnerAddress
TEXAS TECH UNIVERSITY SYSTEMOFFICE OF RESEARCH COMMERCIALIZATION P O BOX 42007 LUBBOCK TX 79409-2007

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Garg, Himanshu El Paso, US 11 22
Joshi, Anjali El Paso, US 11 4

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