Method of producing herpes simplex virus amplicons, resulting amplicons, and their use
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United States of America Patent
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Jan 10, 2012
Grant Date -
Jun 3, 2004
app pub date -
May 23, 2001
filing date -
May 23, 2001
priority date (Note) -
Expired
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Abstract
The present invention relates to a method for producing herpes simplex virus (HSV) amplicon particles which includes co-transfecting a host cell with the following: (i) an amplicon vector comprising an HSV origin of replication, an HSV cleavage/packaging signal, and a heterologous transgene expressible in a patient, (ii) one or more vectors individually or collectively encoding all essential HSV genes but excluding all cleavage/packaging signals, and (iii) a vhs expression vector encoding a virion host shutoff protein; and then isolating HSV amplicon particles produced by the host cell, the HSV amplicon particles including the transgene. Also disclosed are a system and a kit for preparing HSV amplicon particles, HSV amplicon particles prepared according to the process of the present invention, and their use.
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