Systems and methods for thermometry and theranostic applications

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United States of America Patent

PATENT NO 11022500
APP PUB NO 20190293498A1
SERIAL NO

16304408

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Abstract

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In one aspect, methods of measuring the temperature of an environment are described herein. In some embodiments, such a method comprises (a) disposing a population of ultrasound-switchable fluorophores in the environment, the population comprising n differing fluorophores having n differing switching threshold temperatures; (b) exposing the environment to an ultrasound beam to create an activation region having a temperature greater than or equal to one or more of the switching threshold temperatures; (c) disposing the fluorophores within the activation region to switch at least one fluorophore from an off state to an on state; (d) exposing the environment to up to n beams of electromagnetic radiation, thereby exciting at least one fluorophore in the on state; (e) detecting up to n photoluminescence signals emitted by the fluorophores; and (f) correlating the photoluminescence signals with up to n temperatures or temperature ranges.

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Patent Owner(s)

  • BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Yao, Tingfeng Arlington, US 3 0
Yu, Shuai Mansfield, US 4 0
Yuan, Baohong Arlington, US 11 58

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