Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly

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United States of America Patent

PATENT NO 11891434
APP PUB NO 20180258161A1
SERIAL NO

15988348

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Abstract

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An objective of the present invention is to provide methods for promoting antigen uptake into cells by antigen-binding molecules, methods for increasing the number of times of antigen binding by one antigen-binding molecule, methods for promoting reduction of the antigen concentration in plasma by administering antigen-binding molecules, and methods for improving the plasma retention of an antigen-binding molecule, as well as antigen-binding molecules that allow enhanced antigen uptake into cells, antigen-binding molecules having an increased number of times of antigen binding, antigen-binding molecules that can promote reduction of the antigen concentration in plasma when administered, antigen-binding molecules with improved plasma retention, pharmaceutical compositions comprising the above antigen-binding molecules, and methods for producing them. The present inventors revealed that the above objective can be achieved by using antigen-binding molecules that show calcium-dependent antigen-antibody reaction.

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Patent Owner(s)

  • CHUGAI SEIYAKU KABUSHIKI KAISHA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Baba, Takeshi Shizuoka, JP 72 1100
Funaki, Miho Shizuoka, JP 8 98
Hironiwa, Naoka Shizuoka, JP 41 446
Igawa, Tomoyuki Shizuoka, JP 224 5021
Ishii, Shinya Shizuoka, JP 68 1159
Maeda, Atsuhiko Shizuoka, JP 86 2037
Nezu, Junichi Shizuoka, JP 17 353
Ruike, Yoshinao Shizuoka, JP 20 302
Shimizu, Shun Shizuoka, JP 29 268

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