Low affinity poly(AD-ribose) polymerase 1 dependent cytotoxic agents

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United States of America Patent

PATENT NO 11542282
APP PUB NO 20200407374A1
SERIAL NO

16976515

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Abstract

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The present disclosure provides compounds of Formula (I) or (II), pharmaceutically acceptable salt, isotopic variant, stereoisomer, or a mixture thereof. Also provided are pharmaceutical compositions comprising a compound, methods of treating a poly(ADP-ribose)polymerase-1-mediated disease or disorder in a subject, methods of detecting a poly(ADP-ribose)polymerase-1-mediated neurodegenerative disease or disorder, or methods of monitoring cancer treatment in a subject. In some embodiments, the poly(ADP-ribose)polymerase-1-mediated disease or disorder is a neurodegenerative disease or cancer.

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  • THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Mach, Robert H Wallingford, US 24 109
Makvandi, Mehran Philadelphia, US 3 0
Puentes, Laura Philadelphia, US 1 0
Reilly, Sean W Philadelphia, US 4 5

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