Cell-based screening methods
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United States of America Patent
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Aug 1, 2006
Grant Date -
Aug 12, 2004
app pub date -
Feb 3, 2004
filing date -
Mar 9, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Cell-based screening methods for determining kinase activity are provided. The methods utilize existing cellular pathways that are regulated by kinases. In one embodiment, various components of a ubiquitin-mediated degradation pathway are modified to create an assay that can be used to screen for a molecule that modulates the activity of a kinase of interest that otherwise does not regulate the degradation pathway. In another embodiment, various components of a protein translocation pathway are modified to screen for a molecule that modulates the activity of a kinase of interest that otherwise does not regulate the translocation pathway.
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