Method of preparing T cells with increased activity

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11903967
APP PUB NO 20190209612A1
SERIAL NO

16188185

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides a method of preparing a population of genetically modified cells which comprise a chimeric antigen receptor (CAR) or a transgenic T-cell receptor (TCR) comprising: providing a starting population of cells; depleting said starting population of cells which express a target antigen; and introducing into a cell in the depleted starting population a nucleic acid sequence which encodes a CAR or transgenic TCR against the target antigen. The present invention also provides genetically modified cells, pharmaceutical compositions and pharmaceutical compositions for use in the treatment and/or prevention of disease.

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Patent Owner(s)

  • AUTOLUS LIMITED

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beswick, Richard London, GB 4 17
Chan, Emma London, GB 1 5
Faulkner, James London, GB 3 27
Kotsopoulou, Ekaterini London, GB 14 27
Petticone, Carlotta London, GB 1 5
Pulé, Martin London, GB 132 254

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