Oral pharmaceutical dosage forms for pulsatile delivery of an antiarrhythmic agent
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United States of America Patent
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Nov 11, 2003
Issued Date -
N/A
app pub date -
Aug 14, 2001
filing date -
Aug 14, 2000
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Novel pharmaceutical dosage forms provide for pulsatile delivery of an antiarrhythmic agent that releases the drug in spaced apart 'pulses.' The dosage forms are comprised of first, second and optional third dosage units, with each dosage unit having a different drug release profile. The dosage forms may comprise capsules housing compressed tablets or drug-containing beads, granules, or particles or may comprise a single tablet with the first, second and optional third dosage units incorporated therein, or a 'coated core' dosage form. Methods of treatment using the pharmaceutical dosage forms are provided as well.
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