CD123 binding proteins and related compositions and methods
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United States of America Patent
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Mar 26, 2024
Grant Date -
Nov 17, 2022
app pub date -
Dec 21, 2021
filing date -
Sep 21, 2016
priority date (Note) -
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status (Latency Note)
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Abstract
The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain. Such molecules are useful for the treatment of cancer. The protein molecule binding to CD123 may have a second binding domain that binds to another target. In one embodiment, multi-specific polypeptide molecules bind both CD123-expressing cells and the T-cell receptor complex on T-cells to induce target-dependent T-cell cytotoxicity, activation, and proliferation. The disclosure also provides pharmaceutical compositions comprising the CD123-binding polypeptide molecules, nucleic acid molecules encoding these polypeptides and methods of making these molecules.
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