2-Pyrimidineamine derivatives and processes for their preparation
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United States of America Patent
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Sep 5, 2000
Grant Date -
N/A
app pub date -
Oct 27, 1997
filing date -
Oct 28, 1996
priority date (Note) -
Expired
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Abstract
Compounds of general formula (1) ##STR1## are described wherein: Ar is an optionally substituted aromatic group; R.sup.2 is a hydrogen or halogen atom or a group --X.sup.1 --R.sup.2a where X.sup.1 is a direct bond or a linker atom or group, and R.sup.2a is an optionally substituted straight or branched chain alkyl, alkenyl or alkynyl group; R.sup.3 is an optionally substituted heterocycloalkyl group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are selective protein tyrosine kinase inhibitors, particularly the kinases ZAP-70 and syk and are of use in the prophylaxis and treatment of immune or allergic diseases and diseases involving inappropriate platelet activation.
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