Methods of identifying modulators of bitter taste using hT2R50 receptors
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United States of America Patent
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Jul 17, 2012
Grant Date -
Mar 3, 2011
app pub date -
Oct 8, 2010
filing date -
Sep 5, 2006
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Abstract
The present invention relates to the discovery of a novel haplotype of the human taste receptor hT2R50 in the T2R taste receptor family that responds to particular bitter ligands, i.e., 2-acetylpyrazine and ethylpyrazine. The present invention also relates to the use of this novel haplotype in assays for identifying ligands that modulate the activation of the hT250 taste receptor. These compounds potentially may be used as additives in foods, beverages and medicinals for modifying (blocking) hT2R50-associated bitter taste.
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