CRISPR/Cas screening platform to identify genetic modifiers of tau seeding or aggregation

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United States of America Patent

PATENT NO 11845931
APP PUB NO 20200299682A1
SERIAL NO

16821453

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Abstract

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Cas-protein-ready tau biosensor cells, CRISPR/Cas synergistic activation mediator (SAM)-ready tau biosensor cells, and methods of making and using such cells to screen for genetic modifiers of tau seeding or aggregation are provided. Reagents and methods for sensitizing such cells to tau seeding activity or tau aggregation or for causing tau aggregation are also provided.

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Patent Owner(s)

  • REGENERON PHARMACEUTICALS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fury, Wen New York, US 12 56
Koss, Matthew Pleasantville, US 8 12
Prissette, Marine Brooklyn, US 8 13
Zambrowicz, Brian Sleepy Hollow, US 186 501

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