Method for characterizing polypeptides
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United States of America Patent
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Jan 16, 2007
Grant Date -
May 5, 2005
app pub date -
Jun 7, 2002
filing date -
Jun 7, 2001
priority date (Note) -
Expired
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Abstract
Provided is a method for characterizing a polypeptide, which method comprises the steps of: (a) optionally reducing cysteine disulphide bridges in the polypeptide to form free thiols, and capping the free thiols; (b) cleaving the polypeptide with a sequence specific cleavage reagent to form peptide fragments; (c) optionally deactivating the cleavage reagent; (d) capping one or more .epsilon.-amino groups that are present with a lysine reactive agent; (e) analyzing peptide fragments by mass spectrometry to form a mass fingerprint for the polypeptide; and (f) determining the identity of the polypeptide from the mass fingerprint.
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