Compositions and methods for modulating growth of a genetically modified gut bacterial cell

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United States of America Patent

PATENT NO 11254918
APP PUB NO 20210054356A1
SERIAL NO

17091931

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Abstract

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Compositions and methods are provided for modulating growth of a genetically modified bacterial cell present in a human organ, for modulating growth of a genetically modified bacterial cell in an organ (e.g., gut), for displacing at least a portion of a population of bacterial cells in an organ, and for facilitating gut colonization by a genetically modified bacterial cell. Also provided are genetically modified bacterial cells, e.g., cells that include a heterologous carbohydrate-utilization gene or gene set that provides for the ability to utilize as a carbon source a rare carbohydrate of interest that is utilized as a carbon source by less than 50% of bacterial cells present in a human microbiome.

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Patent Owner(s)

  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; NOVOME BIOTECHNOLOOIES, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DeLoache, William C Oakland, US 8 15
Sonnenburg, Justin L Redwood City, US 15 21
Stanley, Elizabeth Portola Valley, US 9 2
Whitaker, Weston R Daly City, US 8 0

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