Methods of treatment utilizing binding proteins of the interleukin-21 receptor
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United States of America Patent
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May 15, 2012
Grant Date -
Dec 3, 2009
app pub date -
May 26, 2009
filing date -
May 23, 2008
priority date (Note) -
Expired
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Abstract
The present invention provides binding proteins and antigen-binding fragments thereof, including human antibodies, that specifically bind to the human interleukin-21 receptor (IL-21R), and methods of using them. The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used, e.g., in diagnosing, treating, and/or preventing IL-21R-associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, and other immune system disorders.
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