Antibody libraries with maximized antibody developability characteristics

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United States of America Patent

PATENT NO 11920258
APP PUB NO 20210171936A1
SERIAL NO

17163170

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Antibody libraries comprising a plurality of heavy chain variable domains and/or a plurality of light chain variable domains, which comprise complementary determining regions (CDRs) found in naturally-occurring human antibodies, and methods of making such antibody libraries. The antibody libraries are free of members that comprise one or more liabilities affecting one or more features of such members. Further, the antibody libraries comprise members having heavy chain and/or light chain CDRs not found in the same naturally-occurring human antibody.

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Patent Owner(s)

  • RULES-BASED MEDICINE INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bradbury, Andrew Raymon Morton Santa Fe, US 5 1
Erasmus, Michael Frank Santa Fe, US 5 1
Teixeira, Andre Santa Fe, US 3 1

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