Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage
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United States of America Patent
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Apr 13, 2010
Grant Date -
Apr 24, 2008
app pub date -
Oct 19, 2007
filing date -
Oct 23, 2006
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Abstract
The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-1 to attract T cells. The mutants may be attached to membranes formed by self-assembling peptides and then implanted at sites of tissue damage to help promote repair.
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