Catecholamine enzyme fusions

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 11279954
APP PUB NO 20200040361A1
SERIAL NO

16454024

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Abstract

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Provided is a construct comprising (i) a nucleotide sequence which encodes tyrosine hydroxylase (TH), (ii) a nucleotide sequence which encodes GTP-cyclohydrolase I (CH1) and (iii) a nucleotide sequence which encodes Aromatic Amino Acid Dopa Decarboxylase (AADC) wherein the nucleotide sequence encoding TH is linked to the nucleotide sequence encoding CH1 such that they encode a fusion protein TH-CH1. Also provided is a construct comprising (i) a nucleotide sequence which encodes tyrosine hydroxylase (TH), (ii) a nucleotide sequence which encodes GTP-cyclohydrolase I (CH1) and (iii) a nucleotide sequence which encodes Aromatic Amino Acid Dopa Decarboxylase (AADC) wherein the nucleotide sequence encoding AADC is linked to the nucleotide sequence encoding TH such that they encode a fusion protein AADC-TH or TH-AADC. Further provided is a viral vector comprising such nucleotide sequences and its use in the treatment and/or prevention of Parkinson's disease.

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Patent Owner(s)

  • OXFORD BIOMEDICA (UK) LTD.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kingsman, Alan John Oxford, GB 40 356
Mitrophanous, Kyriacos A Oxford, GB 13 99
Ralph, Scott Oxford, GB 6 76
Stewart, Hannah Oxford, GB 5 2

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