Manufacture of alpha-arylalkanoic acids and precursors

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United States of America Patent

PATENT NO 4542237
SERIAL NO

06502036

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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.alpha.-Arylalkanoic acids or esters, orthoesters or amides thereof are prepared by forming an .alpha.-hydroxy ketal or thioketal of an aryl alkyl ketone, activating the .alpha.-hydroxy substituent with an esterifying agent to form the corresponding ketal or thioketal ester substrate, wherein the ester group is sufficiently labile to non-catalytically disassociate from the substrate in a protic or dipolar, aprotic solvent, maintaining the ester substrate in contact with the protic or dipolar, aprotic solvent or mixtures thereof for a time sufficient to form the corresponding .alpha.-arylakanoic acid or ester, orthoester or amide thereof, and optionally concomitantly or sequentially hydrolyzing any ester, orthoester or amide formed to the corresponding .alpha.-arylalkanoic acid.

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Patent Owner(s)

  • SYNTEX PHARMACEUTICALS, LTD.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Schloemer, George C Lyons, CO 20 92

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