Photosensitizing antibody-fluorophore conjugates

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United States of America Patent

PATENT NO 8524239
APP PUB NO 20120010558A1
SERIAL NO

13180111

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Abstract

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The present disclosure relates to compositions and methods of killing cells in vitro or in vivo. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein. In particular examples the antibody recognizes a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm−2, thereby killing the cell. Also provided are wearable devices that include an article of clothing, jewelry, or covering; and an NIR LED incorporated into the article, which can be used with the disclosed methods.

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Patent Owner(s)

  • THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRECTARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bernardo, Marcelino Germantown, US 3 62
Choyke, Peter Bethesda, US 16 175
Kobayashi, Hisataka Laurel, US 29 208
Mitsunaga, Makoto Rockville, US 4 39

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