recombinanr xiexumapoeozoite protein compositions and method for vaccine delivery

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United States of America Patent

PATENT NO 11583578
SERIAL NO

16607917

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Abstract

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The invention relates to pharmaceutical compositions comprising at least one antigen and an adjuvant composition, where the adjuvant composition comprises a saponin and a liposome. The liposome of the composition comprises monophosphoryl lipid A (MPLA), cholesterol and a phospholipid that is in a liquid crystalline state at greater than or equal to 23° C., and the concentration of cholesterol to lipid in the liposome is greater than 50% (mol/mol). The antigen in the composition is a soluble Plasmodium falciparum recombinant circumsporozoite protein (rCSP) comprising the amino acid sequence of SEQ ID NO:1, or a P. falciparum rCSP peptide that is at least 95% identical to the amino acid sequence of SEQ ID NO:1.

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Patent Owner(s)

Patent OwnerAddress
THE HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE INC6720-A ROCKLEDGE DRIVE SUITE 100 BETHESDA MD 20817

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alving, Carl Bethesda, US 3 5
Beck, Zoltan Rockville, US 3 3
Dutta, Sheetij Silver Spring, US 10 71
Matyas, Gary Olney, US 1 0

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