Monofunctional polyethylene glycol aldehydes
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United States of America Patent
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Jul 12, 2005
Grant Date -
Feb 19, 2004
app pub date -
May 7, 2003
filing date -
Dec 11, 2001
priority date (Note) -
Expired
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Abstract
The present invention provides novel monofunctional polyethylene glycol aldehydes for the pegylation of therapeutically active proteins. The pegylated protein conjugates that are produced, retain a substantial portion of their therapeutic activity and are less immunogenic than the protein from which the conjugate is derived. New syntheses for preparing such aldehydes are described.
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