Antibody molecules specific to human tumor necrosis factor alpha
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United States of America Patent
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Jul 22, 2008
Grant Date -
Oct 19, 2006
app pub date -
Mar 13, 2006
filing date -
Jun 6, 2000
priority date (Note) -
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Abstract
There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF.alpha.. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF.alpha..
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