Annexin derivatives with endogenous chelation sites
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United States of America Patent
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Dec 21, 2004
Issued Date -
N/A
app pub date -
Oct 3, 2001
filing date -
Jun 1, 1999
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Expired
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Abstract
Modified annexins having an N-terminal chelation site comprising an amino acid extension are disclosed. The amino acid extension includes an amino acid sequence X.sub.1 -Gly-X.sub.2, where X.sub.1 and X.sub.2 are selected from Gly and Cys, where at least one of X.sub.1 or X.sub.2 is Cys. Radionuclides are readily chelated by the modified annexins to provide radiolabeled annexins useful in imaging vascular thrombi and apoptosis in vivo.
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