Generation of muscle lineage cells and therapeutic uses thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11376257
APP PUB NO 20210060024A1
SERIAL NO

16283653

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Methods and compositions for producing mature myotubes are provided herein. In some instances, the method involves contacting a myoblast in an in vitro culture with a compound, wherein the contacting the myoblast in the in vitro culture with the compound results in generation of mature myotubes or myotube-like cells. In some cases, methods of treatment are provided involving treating a subject with a compound such as a Chk1 inhibitor in order to treat muscle deficiency. The compound may be administered as a stand-alone therapy or in combination with a cell therapy, such as introduction of muscle precursor cells such as satellite cells or myoblasts. Methods for identifying compounds that induce formation of mature myotubes or myotube-like cells from myoblasts are also provided herein, as well as methods of using the identified compounds to treat subjects.

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Patent Owner(s)

  • SONIC MASTER LIMITED

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
De, La Garza Anabel San Diego, US 4 9
Kiselyov, Alexander San Diego, US 29 267
Schmidt, Uli San Diego, US 8 13

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