Conjugates comprising human IL-18 and substitution mutants thereof
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United States of America Patent
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Dec 25, 2007
Grant Date -
Jan 13, 2005
app pub date -
Apr 14, 2004
filing date -
Apr 15, 2003
priority date (Note) -
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Abstract
Human interleukin-18 (IL-18) polypeptides and substitution mutants thereof were conjugated to water-soluble polymers at specific sites on the human IL-18 protein. These conjugated human IL-18 and substitution mutants thereof retain biological activity. These conjugated cytokines demonstrate enhanced and unexpected biological properties when compared to the corresponding unconjugated cytokines.
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