Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 11965021
APP PUB NO 20210107976A1
SERIAL NO

16608366

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Abstract

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The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells.

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Patent Owner(s)

  • EUREKA THERAPEUTICS, INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Horan, Lucas Emeryville, US 13 52
Liu, Hong El Sobrante, US 502 2790
Liu, Lianxing San Francisco, US 8 8
Staley, Binnaz K San Carlos, US 4 5
Xu, Yiyang Pleasanton, US 33 94
Yun, Hongruo San Francisco, US 6 6
Zhang, Pengbo Fremont, US 15 48

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