Recombinant polymerases for improved single molecule sequencing

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United States of America Patent

PATENT NO 11746338
APP PUB NO 20210261928A1
SERIAL NO

17191141

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Abstract

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Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, increased yield, increased thermostability, increased accuracy, increased speed, increased readlength, and the like. Also provided are nucleic acids which encode the polymerases with the aforementioned phenotypes, as well as methods of using such polymerases to make a DNA or to sequence a DNA template.

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Patent Owner(s)

  • PACIFIC BIOSCIENCES OF CALIFORNIA, INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Emig, Robin Pleasanton, US 32 1918
He, Molly San Diego, US 76 1362
Jia, Lei Newbury Park, US 118 1662
Kamtekar, Satwik Mountain View, US 46 580
Lee, Walter H Campbell, US 6 29
Miller, Erik Berkeley, US 82 895
Park, Insil Fremont, US 19 949

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