Cationic polymer and lipoprotein-containing system for gene delivery
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United States of America Patent
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Oct 21, 1997
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N/A
app pub date -
Jul 3, 1996
filing date -
Jul 3, 1996
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Abstract
A composition for delivery of a selected nucleic acid into a targeted host cell comprises a complex of a hydrophobized, positively charged, biocompatible polymer; a lipoprotein; and a selected nucleic acid. Hydrophobic and electrostatic interactions between the components provide for the formation of the condensed DNA-containing complex. Preferred embodiments of the complex have a slightly positive surface charge and an average diameter of about 200 nm. Plasmids and oligonucleotides can be efficiently delivered with such compositions. A method of delivering a selected nucleic acid to a host cell is also disclosed.
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