Neutralizing monoclonal antibodies against the Nogo-66 receptor (NgR)
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United States of America Patent
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Mar 15, 2011
Grant Date -
Nov 13, 2008
app pub date -
Nov 21, 2007
filing date -
Nov 21, 2006
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Abstract
The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
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