Methods and systems for determining spatial patterns of biological targets in a sample

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United States of America Patent

PATENT NO 11821024
APP PUB NO 20230304074A1
SERIAL NO

18129357

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Abstract

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The present disclosure provides methods and assay systems for use in spatially encoded biological assays, including assays to determine a spatial pattern of abundance, expression, and/or activity of one or more biological targets across multiple sites in a sample. In particular, the biological targets comprise proteins, and the methods and assay systems do not depend on imaging techniques for the spatial information of the targets. The present disclosure provides methods and assay systems capable of high levels of multiplexing where reagents are provided to a biological sample in order to address tag the sites to which reagents are delivered; instrumentation capable of controlled delivery of reagents; and a decoding scheme providing a readout that is digital in nature.

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Patent Owner(s)

  • PROGNOSYS BIOSCIENCES, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chee, Mark S San Diego, US 218 18601
Routenberg, David A San Diego, US 19 1965

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