Method for the preparation of [1,2,4]-triazolo[4,3-a]pyridines

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United States of America Patent

PATENT NO 9643984
SERIAL NO

14900976

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Abstract

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Disclosed herein are methods for preparing [1,2,4]triazolo[4,3-a]pyridines, particularly (R)-6-(1-(8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one, and precursors thereof, such as a method comprising reacting (R)—N-(3-fluoro-5-(1methyl-1H-pyrazol-4-yl) pyridin-2-yl)-2-(3-(2-methoxyethoxy)-5-oxo-1,6-naphthyridin-6(5H)yl) propanehydrazide (“HYDZ”): (HYDZ) under conditions sufficient to form (R)-6-(1-(8-fluoro-6-(1-methyl-IH-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one (“A”): (A)

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Patent Owner(s)

  • AMGEN INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bio, Matthew Santa Barbara, US 17 47
Fang, Eric Somerville, US 5 43
Milne, Jacqueline E Simi Valley, US 1 2
Wiedemann, Sean Cambridge, US 3 13
Wilsily, Ash Somerville, US 1 2

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