Methods and compositions for specific inhibition of protein splicing by small molecules
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United States of America Patent
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Jun 30, 2009
Grant Date -
Sep 28, 2006
app pub date -
Jan 24, 2006
filing date -
Jan 24, 2005
priority date (Note) -
Expired
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Abstract
The present invention relates to compositions (i.e., various organic small molecules as exemplified herein) and methods for the inhibition of protein splicing and especially relates to the inhibition of protein autosplicing of intein-containing proteins. Additionally, the present invention relates to the use of the inhibitors of protein splicing of the invention for the treatment of various diseases including but not limited to tuberculosis. Furthermore, the invention provides the first instance of small molecule inhibitors of protein splicing with drug-like characteristics.
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