Amphiphilic dendrimers complexed with siRNA for treatment of cancer

Number of patents in Portfolio can not be more than 2000

United States of America

PATENT NO 10421968
APP PUB NO 20180265872A1
SERIAL NO

15459806

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention pertains to amphiphilic dendrimers complexed with Bcl3 siRNA. The amphiphilic dendriplexes described herein are biodegradable and exhibit enhanced siRNA delivery. The amphiphilic dendriplexes containing Bcl3 siRNA inhibit cancer cell/tumor growth in vitro and in vivo without toxicity. Accordingly, an embodiment of the invention provides a method of treating a cancer, particularly, nasopharyngeal carcinoma, by administering to a subject in need thereof, a therapeutic amount of amphiphilic dendrimers complexed with Bcl3 siRNA. Pharmaceutical compositions containing the amphiphilic dendrimers complexed with Bcl3 siRNA are also provided.

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Patent Owner(s)

  • VERSITECH LIMITED; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; UNIVERSITÉ´ D'AIX-MARSEILLE; THE CHINESE UNIVERSITY OF HONG KONG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lo, K W Hong Kong, CN 1 0
Ma, Jing Hong Kong, CN 102 209
Peng, Ling Paris, FR 17 19
Wong, Alice S T Hong Kong, CN 1 0

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