Stabilized chimeric Fabs

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United States of America Patent

PATENT NO 11965019
APP PUB NO 20200308270A1
SERIAL NO

16624479

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Provided herein are stabilized chimeric Fabs derived from a parent chimeric Fab having a lambda light chain. The stabilized chimeric Fabs comprise an immunoglobulin heavy chain polypeptide construct from the parent chimeric Fab, having a CH1 sequence and a VH sequence, as well as a Vlambda-Ckappa chimeric light chain construct. The Vlambda sequence of the chimeric light chain construct corresponds to that of the parent chimeric Fab, and comprises one or more stabilizing amino acid modifications that increase the thermal stability of the stabilized chimeric Fab compared to the parent chimeric Fab. The stabilized Fabs are useful as therapeutic polypeptides, or can be used to prepare antibody constructs in other formats. The stabilized chimeric Fabs may also be useful generally to increase the stability of antibodies having lambda light chains.

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Patent Owner(s)

  • ZYMEWORKS BC INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chou, Yang-Chieh San Francisco, US 4 27
Urosev, Dunja Vancouver, CA 14 181

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