Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen
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United States of America Patent
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Nov 8, 2005
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N/A
app pub date -
Apr 28, 2000
filing date -
Mar 25, 1996
priority date (Note) -
Expired
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Abstract
The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, thirty-five monoclonal antibodies reactive with PSMA expressed on the cell surface are exemplified. Additionally, the present invention relates to a novel protein variant (PSM′) of the PSMA detected by a number of the antibodies of the invention. The hydrolase activity of PSMA and PSM′ allows the use of an immunoenzymatic assay for their detection.
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