Luteinizing hormone receptor binding agents and luteinizing hormone agonists to identify, expand, ablate and modify stem cells

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United States of America Patent

PATENT NO 11786557
APP PUB NO 20200237827A1
SERIAL NO

16753277

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Abstract

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The use of luteinizing hormone receptor (LHR) binding agents and luteinizing hormone (LH) agonists to enrich for primitive hematopoietic stem cell (pHSC) populations, to target pHSC for ablation, and/or to expand pHSC populations are described. The methods can be used to prepare therapeutic hematopoietic stem cell (HSC) populations, to prepare patients for therapeutic HSC transplants, and/or to treat malignancies, such as those associated with hyperproliferative HSC.

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Patent Owner(s)

  • FRED HUTCHINSON CANCER CENTER

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dudakov, Jarrod Seattle, US 7 2
James, Scott New York, US 17 364
Kiem, Hans-Peter Seattle, US 21 99
Radtke, Stefan Seattle, US 4 9
van, den Brink Marcel New York, US 13 24
Velardi, Enrico New York, US 4 0

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