Dual function antibodies specific to glycosylated PD-L1 and methods of use thereof

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United States of America Patent

PATENT NO 11660352
APP PUB NO 20190083644A1
SERIAL NO

16086582

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Abstract

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Antibodies that bind specifically to glycosylated PD-L1 relative to unglycosylated PD-L1, block binding of PD-L1 to PD-1 and promote internalization and degradation of PD-L1 are provided. Antibodies that recognize specific epitopes on glycosylated PD-L1 protein and that exhibit the dual functions of both blocking the binding of PD-L1 to PD-1 and also facilitating the internalization of PD-L1 on cells are provided. In some aspects, PD-L1 polypeptides comprising glycosylated amino acid residues at amino and carboxy terminal positions of the PD-L1 extracellular domain are also provided. Methods for using such antibodies for the treatment of cancer, particularly PD-L1 positive cancer, are also provided.

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Patent Owner(s)

  • STCUBE, INC.; BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chung, Ezra M North Potomac, US 5 19
Han, Kyu Lee Gaithersburg, US 2 12
Hung, Mien-Chie Houston, US 54 319
Kim, Yong-Soo Rockville, US 91 767
Li, Chia-Wei Houston, US 12 34
Lim, Seung-Oe Houston, US 6 20
Park, Andrew H Gaithersburg, US 3 13
Yoo, Stephen S Centreville, US 8 24

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