Pharmaceutical compositions containing anti-Fas antibody
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United States of America Patent
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Jun 8, 2004
Grant Date -
Aug 1, 2002
app pub date -
Nov 20, 2001
filing date -
May 24, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A pharmaceutical composition containing an anti-human Fas antibody having apoptosis inducing activity and a compound having a folate antagonist activity or a dihydrofolate reductase inhibiting activity, as active ingredients for the prophylaxis and/or treatment of an autoimmune disease or rheumatoid arthritis. According to the present invention, the amount of the anti-Fas antibody to be used can be reduced and thereby the possibility that a patient may become tolerant to anti-Fas antibody as a result of the production of antibodies against the anti-Fas antibody in the patient's body or the like can be decreased, and thus is provided a pharmaceutical composition which can be used for a long time.
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