Isoxazolo-pyrazine derivatives
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United States of America Patent
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Mar 8, 2011
Grant Date -
Oct 7, 2010
app pub date -
May 27, 2010
filing date -
Dec 4, 2007
priority date (Note) -
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Abstract
The invention relates to isoxazolo-pyrazine derivatives and their pharmaceutically acceptable salts having affinity and selectivity for the GABA A α5 receptor binding site, their manufacture, and pharmaceutical compositions containing them. The compounds of the present invention are inverse agonists of GABAAα5. The invention also relates to methods for enhancing cognition and for treating cognitive disorders like Alzheimer's disease.
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