Human Smad3 and Smad4 are sequence-specific transcription activators
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United States of America Patent
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Aug 8, 2000
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app pub date -
Mar 13, 1998
filing date -
Mar 13, 1998
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Abstract
Two human Smad proteins (Smad3 and Smad4) specifically recognize an identical 8 bp palindromic sequence (GTCTAGAC) (SEQ ID NO: 1). Tandem repeats of this palindrome confer striking TGF-.beta. responsiveness to a minimal promoter. This responsiveness is abrogated by targeted deletion of the cellular Smad4 gene. DNA molecules comprising the 8 bp palindromic sequence can be used in assays for drug screening and diagnostically.
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