Modified proteins, designer toxins, and methods of making thereof
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United States of America Patent
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Aug 1, 2006
Grant Date -
Sep 18, 2003
app pub date -
Feb 12, 2002
filing date -
Feb 12, 2001
priority date (Note) -
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Abstract
The present invention concerns methods of reducing the antigenicity of a proteinaceous compound while maintaining the compounds biological activity, as well as proteinaceous compositions with biological activity but reduced antigenicity. These methods and compositions have significant benefits to a subject in need of such compounds and compositions. Also included are modified toxin compounds that are truncated and/or possess reduce antigenicity. Such designer toxins have therapeutic, diagnostic, and preventative benefits, particularly as immunotoxins. Methods of treating cancer using these immunotoxins are provided.
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