Soluble polypeptide fractions of the LAG-3 protein, production method, therapeutic composition, anti-idiotype antibodies

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United States of America Patent

PATENT NO 5955300
SERIAL NO

08737271

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Soluble polypeptide fraction consisting of all or part one at least of the four immunoglobulin-type extracellular LAG-3 protein domains (amino acids 1-159, 160-230, 240-330 and 331-412 of the SEQ ID NO:1 sequence) or consisting of one peptide sequence derived from these domains by replacement, addition or deletion of one or more amino acids. The fraction of the invention has a specificity at least equal to that of LAG-3 in relation to its ligand.

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Patent Owner(s)

  • INSTITUT GUSTAVE ROUSSY;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);MERCK SERONO SA

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Faure, Florence Paris, FR 3 111
Hercend, Thierry Charenton le Pont, FR 20 423
Huard, Bertrand L'Haye les Roses, FR 8 162
Triebel, Frederic Versailles, FR 43 683

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