Combination cancer chemotherapy

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8481529
APP PUB NO 20090270377A1
SERIAL NO

12301217

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Abstract

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Provided is a method for improving treatment of a neoplastic condition by combining a therapeutically effective amount of a polyADP-ribose polymerase inhibitor with a therapeutically effective amount of a compound which triggers the release of nucleolin from the G-quadruplexes in rDNA. As specifically exemplified, the compound which increases nucleolin binding is a substituted quinobenzoxazine analog, for example CX-3543.

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Patent Owner(s)

  • THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Guzman, Mary Tucson, US 1 0
Hurley, Laurence H Tucson, US 23 658

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