Compositions and methods for enhancing paracellular permeability across epithelial and endothelial barriers
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United States of America Patent
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May 11, 2010
Grant Date -
Aug 22, 2002
app pub date -
Oct 10, 2001
filing date -
Oct 10, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Compositions and methods for enhancing paracellular permeability at an absorption site in a subject are disclosed. The method includes: (a) administering an effective amount of a phospholipase C inhibitor to a subject at a time in which enhanced paracellular permeability is desired; and (b) enhancing paracellular permeability in the subject at the absorption site through the administering of the effective amount of the phospholipase C inhibitor. The disclosed compositions and methods provide enhanced absorption of a hydrophilic drug in a subject.
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