Protein biomarker and uses thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 11873344
APP PUB NO 20200115467A1
SERIAL NO

16547440

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low. The invention is also directed to methods of performing an ELISA, including sequential steps of contacting a solid surface with a plurality of solutions each comprising in turn a capture antibody, a blocking agent, a sample suspected of containing an analyte, a detection antibody and an enzyme conjugate, in which the solid surface is subjected to a wash process after each sequential step.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

  • DAIICHI SANKYO CO. LTD.; DAIICHI SANKYO EUROPE GMBH; KINKI UNIVERSITY; AMGEN INC.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beckman, Robert Allen Blue Bell, US 8 10
Blum, Sabine Munich, DE 11 38
Freeman, Daniel J Holmdel, US 26 227
Jin, Xiaoping Hillsborough, US 44 296
Mendell-Harary, Renee Jeanne Skillman, US 8 10
Nakagawa, Kazuhiko Osakasayama, JP 50 524
Schneider, Matthias Neufarn, DE 91 505
Yonesaka, Kimio Osakasayama, JP 6 7

Cited Art Landscape

Load Citation

Patent Citation Ranking

Forward Cite Landscape

Load Citation

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
3.5 Year Payment $1600.00 $800.00 $400.00 Jul 16, 2027
7.5 Year Payment $3600.00 $1800.00 $900.00 Jul 16, 2031
11.5 Year Payment $7400.00 $3700.00 $1850.00 Jul 16, 2035
Fee Large entity fee small entity fee micro entity fee
Surcharge - 3.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00